Institutions of the University of Bayreuth
Chair Biochemistry I - Proteinbiochemie der Signaltransduktion

2024

Kynast, Josef:
Towards Modular Protein Detection : Computational Methods to Support the Design of Peptide-Binding Pockets.
Bayreuth , 2024 . - X, 83 P.
( Doctoral thesis, 2024 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

2023

Adolph, Ramona S.:
Biochemical and structural characterization of the regulation of human Sirtuin 1 by small molecules and proteins.
Bayreuth , 2023 . - XIV, 192 P.
( Doctoral thesis, 2020 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Kaiser, Jennifer:
Charakterisierung und Anwendung von PAL, eines blaulichtabhängig RNA-bindenden Proteins.
Bayreuth , 2023 . - IV, 110, xxiv P.
( Doctoral thesis, 2020 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Suenkel, Benjamin:
Bioanalytical an mechanistical analysis of isoform specific Sirtuin modulation.
Bayreuth , 2023 . - X, 112 P.
( Doctoral thesis, 2016 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Dietler, Julia:
Mechanistische Charakterisierung und Anwendung von Light-oxygen-voltage Rezeptoren.
Bayreuth , 2023 . - 206 P.
( Doctoral thesis, 2021 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Noske, Jakob ; Kynast, Josef ; Lemm, Dominik ; Schmidt, Steffen ; Höcker, Birte:
PocketOptimizer 2.0 : A modular framework for computer‐aided ligand‐binding design.
In: Protein Science. Vol. 32 (2023) Issue 1 . - No. e4516.
ISSN 1469-896X
DOI der Verlagsversion: https://doi.org/10.1002/pro.4516

Michel, Florian ; Romero-Romero, Sergio ; Höcker, Birte:
Retracing the evolution of a modern periplasmic binding protein.
In: Protein Science. Vol. 32 (2023) Issue 11 . - e4793.
ISSN 1469-896X
DOI der Verlagsversion: https://doi.org/10.1002/pro.4793

Kordes, Sina:
TIM Barrels 2.0 – Stabilizing and Diversifying a De Novo Designed Protein.
Bayreuth , 2023 . - ii, 190 P.
( Doctoral thesis, 2022 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

2022

Weigert, Sebastian ; Perez‐Garcia, Pablo ; Gisdon, Florian J. ; Gagsteiger, Andreas ; Schweinshaut, Kristine ; Ullmann, G. Matthias ; Chow, Jennifer ; Streit, Wolfgang R. ; Höcker, Birte:
Investigation of the halophilic PET hydrolase PET6 from Vibrio gazogenes.
In: Protein Science. Vol. 31 (1 December 2022) Issue 12 . - e4500.
ISSN 1469-896X
DOI der Verlagsversion: https://doi.org/10.1002/pro.4500

Dietler, Julia ; Gelfert, Renate ; Kaiser, Jennifer ; Borin, Veniamin ; Renzl, Christian ; Pilsl, Sebastian ; Ranzani, Américo Tavares ; García de Funtes, Andrés ; Gleichmann, Tobias ; Diensthuber, Ralph P. ; Weyand, Michael ; Mayer, Günter ; Schapiro, Igor ; Möglich, Andreas:
Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine.
In: Nature Communications. Vol. 13 (2022) Issue 1 . - No. 2618.
ISSN 2041-1723
DOI der Verlagsversion: https://doi.org/10.1038/s41467-022-30252-4

Weigert, Sebastian:
Investigation of PET-degrading enzymes and their implications on microplastics.
Bayreuth , 2022 . - IV, 112 P.
( Doctoral thesis, 2022 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Ohlendorf, Robert ; Möglich, Andreas:
Light-regulated Gene Expression in Bacteria : Fundamentals, Advances, and Perspectives.
In: Frontiers in Bioengineering and Biotechnology. Vol. 10 (2022) .
ISSN 2296-4185
DOI der Verlagsversion: https://doi.org/10.3389/fbioe.2022.1029403

Kordes, Sina ; Romero-Romero, Sergio ; Lutz, Leonie ; Höcker, Birte:
A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels.
In: Protein Science. Vol. 31 (2022) Issue 2 . - pp. 513-527.
ISSN 1469-896X
DOI der Verlagsversion: https://doi.org/10.1002/pro.4249

Ferruz, Noelia ; Schmidt, Steffen ; Höcker, Birte:
ProtGPT2 is a deep unsupervised language model for protein design.
In: Nature Communications. Vol. 13 (2022) Issue 1 . - No. 4348.
ISSN 2041-1723
DOI der Verlagsversion: https://doi.org/10.1038/s41467-022-32007-7

2021

Wiese, Jonas Gregor ; Shanmugaratnam, Sooruban ; Höcker, Birte:
Extension of a de novo TIM barrel with a rationally designed secondary structure element.
In: Protein Science. Vol. 30 (May 2021) Issue 5 . - pp. 982-989.
ISSN 1469-896X
DOI der Verlagsversion: https://doi.org/10.1002/pro.4064

Yuan Wahlgren, Weixiao ; Golonka, David ; Westenhoff, Sebastian ; Möglich, Andreas:
Cryo-electron microscopy of Arabidopsis thaliana phytochrome A in its Pr state reveals head-to-head homodimeric architecture.
In: Frontiers in Plant Science. Vol. 12 (April 2021) . - No. 663751.
ISSN 1664-462X
DOI der Verlagsversion: https://doi.org/10.3389/fpls.2021.663751

Lechner, Horst ; Emann, Vincent R. ; Breuning, Matthias ; Höcker, Birte:
An Artificial Cofactor Catalyzing the Baylis-Hillman Reaction with Designed Streptavidin as Protein Host.
In: ChemBioChem. Vol. 22 (2021) Issue 9 . - pp. 1573-1577.
ISSN 1439-7633
DOI der Verlagsversion: https://doi.org/10.1002/cbic.202000880

Weiß, Sandra:
Biochemische und strukturelle Charakterisierung der Regulation von Sirtuinen durch AROS und Kleinmoleküle.
Bayreuth , 2021 . - XV, 122 P.
( Doctoral thesis, 2021 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Kröger, Pascal ; Shanmugaratnam, Sooruban ; Scheib, Ulrike ; Höcker, Birte:
Fine-tuning spermidine binding modes in the putrescine binding protein PotF.
In: Journal of Biological Chemistry. Vol. 297 (2021) Issue 6 . - No. 101419.
ISSN 0021-9258
DOI der Verlagsversion: https://doi.org/10.1016/j.jbc.2021.101419

Ferruz, Noelia ; Michel, Florian ; Lobos, Francisco ; Schmidt, Steffen ; Höcker, Birte:
Fuzzle 2.0 : Ligand Binding in Natural Protein Building Blocks.
In: Frontiers in Molecular Biosciences. Vol. 8 (2021) . - No. 715972.
ISSN 2296-889X
DOI der Verlagsversion: https://doi.org/10.3389/fmolb.2021.715972

Menzel, Teresa ; Weigert, Sebastian ; Gagsteiger, Andreas ; Eich, Yannik ; Sittl, Sebastian ; Papastavrou, Georg ; Ruckdäschel, Holger ; Altstädt, Volker ; Höcker, Birte:
Impact of Enzymatic Degradation on the Material Properties of Poly(Ethylene Terephthalate).
In: Polymers. Vol. 13 (2021) Issue 22 . - No. 3885.
ISSN 2073-4360
DOI der Verlagsversion: https://doi.org/10.3390/polym13223885

Unverzagt, Carlo ; Reif, Andreas ; Lam, Kevin ; Weidler, Sascha ; Lott, Marie ; Boos, Irene ; Lokau, Juliane ; Bretscher, Christian ; Mönnich, Manuel ; Perkams, Lukas ; Schmälzlein, Marina ; Graf, Christopher G. F. ; Fischer, Jan-Patrick ; Lechner, Carolin ; Hallstein, Kerstin ; Becker, Stefan ; Weyand, Michael ; Steegborn, Clemens ; Schultheiss, Gerhard ; Rose-John, Stefan ; Garbers, Christoph:
Natural Glycoforms of Human Interleukin 6 show atypical plasma clearance.
In: Angewandte Chemie International Edition. Vol. 60 (2021) Issue 24 . - pp. 13380-13387.
ISSN 1521-3773
DOI der Verlagsversion: https://doi.org/10.1002/anie.202101496

Dietler, Julia ; Liang, Chen ; Frank, Saskia ; Müller, Ann-Kathrin ; Greiner, Andreas ; Möglich, Andreas:
Photobiologically Directed Assembly of Gold Nanoparticles.
In: Advanced Biology. Vol. 5 (2021) Issue 5 . - Art.Nr. 2000179. - 7 S.
ISSN 2701-0198
DOI der Verlagsversion: https://doi.org/10.1002/adbi.202000179

Ferruz, Noelia ; Schmidt, Steffen ; Höcker, Birte:
ProteinTools : a toolkit to analyze protein structures.
In: Nucleic Acids Research. Vol. 49 (2021) Issue W1 . - W559-W566.
ISSN 1362-4962
DOI der Verlagsversion: https://doi.org/10.1093/nar/gkab375

2020

Stabel, Robert:
Design neuer rotlichtaktivierter Enzyme zur Kontrolle von zyklischen Mononukleotiden.
Bayreuth , 2020 . - V, 132 P.
( Doctoral thesis, 2019 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Ziegler, Thea:
Engineering and Characterization of RNA-binding LOV photoreceptors.
2020 . - 163 P.
( Doctoral thesis, 2019 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

2019

You, Weijie ; Zheng, Wei ; Weiß, Sandra ; Chua, Katrin F. ; Steegborn, Clemens:
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
In: Scientific Reports. Vol. 9 (16 December 2019) Issue 1 . - No. 19176.
ISSN 2045-2322
DOI der Verlagsversion: https://doi.org/10.1038/s41598-019-55654-1

You, Weijie:
Activation and inhibition of Sirt6 by small molecules.
Bayreuth , 2019 . - 120 P.
( Doctoral thesis, 2019 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Möglich, Andreas:
Signal transduction in photoreceptor histidine kinases.
In: Protein Science. (9 August 2019) .
ISSN 1469-896X
DOI der Verlagsversion: https://doi.org/10.1002/pro.3705

Stüven, Birthe ; Stabel, Robert ; Ohlendorf, Robert ; Beck, Julian ; Schubert, Roman ; Möglich, Andreas:
Characterization and engineering of photoactivated adenylyl cyclases.
In: Biological Chemistry. Vol. 400 (2019) Issue 3 . - pp. 429-441.
ISSN 1437-4315
DOI der Verlagsversion: https://doi.org/10.1515/hsz-2018-0375

Dietler, Julia ; Stabel, Robert ; Möglich, Andreas:
Pulsatile illumination for photobiology and optogenetics.
In: Methods in Enzymology. Vol. 624 (2019) . - pp. 227-248.
ISSN 0076-6879
DOI der Verlagsversion: https://doi.org/10.1016/bs.mie.2019.04.005

2018

Lichtenstein, Bruce R. ; Höcker, Birte:
Engineering an AB₅ Protein Carrier.
In: Scientific Reports. Vol. 2018 (23 August 2018) Issue 8 . - No. 12643.
ISSN 2045-2322
DOI der Verlagsversion: https://doi.org/10.1038/s41598-018-30910-y

Pannek, Martin:
Biochemical and structural studies on the mitochondrial Sirtuins 4 and 5.
Bayreuth , 2018 . - 231 P.
( Doctoral thesis, 2018 , University of Bayreuth, Bayreuther Graduiertenschule für Mathematik und Naturwissenschaften - BayNAT)

Hennemann, Julia ; Iwasaki, Roman S. ; Grund, Tamara N. ; Diensthuber, Ralph P. ; Richter, Florian ; Möglich, Andreas:
Optogenetic Control by Pulsed Illumination.
In: ChemBioChem. Vol. 19 (2018) Issue 12 . - pp. 1296-1304.
ISSN 1439-7633
DOI der Verlagsversion: https://doi.org/10.1002/cbic.201800030

2017

Richter, Florian ; Fonfara, Ines ; Gelfert, Renate ; Nack, Jennifer ; Charpentier, Emmanuelle ; Möglich, Andreas:
Switchable Cas9.
In: Current Opinion in Biotechnology. Vol. 48 (2017) . - pp. 119-126.
ISSN 1879-0429
DOI der Verlagsversion: https://doi.org/10.1016/j.copbio.2017.03.025

2016

Ohlendorf, Robert ; Schumacher, Charlotte Helene ; Richter, Florian ; Möglich, Andreas:
Library-Aided Probing of Linker Determinants in Hybrid Photoreceptors.
In: ACS Synthetic Biology. Vol. 5 (2016) Issue 10 . - pp. 1117-1126.
ISSN 2161-5063
DOI der Verlagsversion: https://doi.org/10.1021/acssynbio.6b00028

2014

Kleinbölting, Silke:
Strukturelle und biochemische Charakterisierung der humanen löslichen Adenylyl-Cyclase.
Bayreuth , 2014 . - VII, 135 P.
( Doctoral thesis, 2014 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Nguyen, Giang Thi Tuyet:
Regulation of Mitochondrial Sirtuins Sirt3 and Sirt5 by Small Molecules.
Bayreuth , 2014 . - IX, 92 P.
( Doctoral thesis, 2014 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

Maier, Raimund:
Charakterisierung modularer Peptidyl-Prolyl-cis-trans-Isomerasen.
Bayreuth , 2014 . - 153 P.
( Doctoral thesis, 2014 , University of Bayreuth, Faculty of Biology, Chemistry and Earth Sciences)

2013

Lakshminarasimhan, Mahadevan ; Curth, Ute ; Moniot, Sebastien ; Mosalaganti, Shyamal ; Raunser, Stefan ; Steegborn, Clemens:
Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.
In: Bioscience Report. Vol. 33 (2013) Issue 3 . - pp. 395-404.
ISSN 0144-8463
DOI der Verlagsversion: https://doi.org/10.1042/BSR20120121

Lakshminarasimhan, Mahadevan ; Rauh, David ; Schutkowski, Mike ; Steegborn, Clemens:
Sirt1 activation by resveratrol is substrate sequence-selective.
In: Aging. Vol. 5 (2013) Issue 3 . - pp. 151-154.