Co Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions

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Elfinger, Matthias ; Schönauer, Timon ; Thomä, Sabrina ; Stäglich, Robert ; Zobel, Mirijam ; Senker, Jürgen ; Drechsler, Markus ; Kempe, Rhett:
Co Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions.
In: ChemSusChem. Bd. 14 (2021) Heft 11 . - S. 2360-2366.
ISSN 1864-564X
DOI der Verlagsversion: https://doi.org/10.1002/cssc.202100553

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Abstract

Nanostructured and reusable 3d‐metal catalysts that operate with high activity and selectivity in important chemical reactions are highly desirable. We report here on a cobalt catalyst for the synthesis of primary amines via reductive amination employing hydrogen as the reducing agent and easy to handle ammonia, dissolved in water, as the nitrogen source. Our catalyst operates under very mild conditions (1.5 mol% catalyst loading, 50 °C and 10 bar H 2 pressure) and outperforms commercially available noble metal catalysts (Pd, Pt, Ru, Rh, Ir). We observe a broad scope and a very good functional group tolerance. The key for the high activity seems to be the used support: an N‐doped amorphous carbon material with small and turbostratically disordered graphitic domains. It is microporous with a bimodal size distribution and with basic NH functionalities in the pores.