Photocatalytic Synthesis of Unprotected Sulfonimidamides and Their Application in Photochemical Nitrene Transfer Reactions

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00009054
URN to cite this document: urn:nbn:de:bvb:703-epub-9054-5

Title data

Sliusarevskyi, Ivan ; Diaz, Jordan ; Senapati, Sudip ; Ebel, Ben J. ; Linnartz, Nico J. ; Oppel, Iris M. ; Empel, Claire ; Chan, Philip Wai Hong ; Koenigs, Rene M.:
Photocatalytic Synthesis of Unprotected Sulfonimidamides and Their Application in Photochemical Nitrene Transfer Reactions.
In: Angewandte Chemie International Edition. Vol. 64 (2025) Issue 39 . - e202509870.
ISSN 1521-3773
DOI der Verlagsversion: https://doi.org/10.1002/anie.202509870

	Format: PDF Name: Angew Chem Int Ed - 2025 - Sliusarevskyi - Photocatalytic Synthesis of Unprotected Sulfonimidamides and Their Application.pdf Version: Published Version Available under License Creative Commons BY 4.0: Attribution
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Abstract

The selective incorporation of nitrogen into organic molecules remains a central challenge in modern synthetic chemistry, particularly when aiming to access complex, functionalized scaffolds under mild and sustainable conditions. In this report, we describe a photocatalytic method that employs hydroxylamine-derived nitrene precursors and unprotected sulfinamides under mild conditions, enabling efficient nitrene transfer without the need for stoichiometric amounts of an oxidant. The resulting unprotected sulfonimidamides serve not only as target compounds but also as versatile intermediates for further nitrene-transfer reactions, affording complex sulfur–nitrogen-rich frameworks. Mechanistic studies support a photoinduced single-electron transfer process involving a reactant complex between the photocatalyst and nitrene precursor. This work establishes a general and modular platform for accessing challenging architectures based on sulfonimidamides, expanding the toolkit for late-stage functionalization and heteroatom-rich molecule construction.

Further data

Item Type:	Article in a journal
Keywords:	Amination; Cycloaddition; Nitren; Photocatalysis; Sulfur
DDC Subjects:	500 Science > 540 Chemistry
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry II - Bioorganic Chemistry > Chair Organic Chemistry II - Bioorganic Chemistry - Univ.-Prof. Dr. René M. Koenigs Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry II - Bioorganic Chemistry
Language:	English
Originates at UBT:	Yes
URN:	urn:nbn:de:bvb:703-epub-9054-5
Date Deposited:	31 Mar 2026 08:07
Last Modified:	31 Mar 2026 08:08
URI:	https://epub.uni-bayreuth.de/id/eprint/9054

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