The efficient synthesis of three-membered rings via photo- and electrochemical strategies

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Han, Xinyu ; Zhang, Na ; Li, Qiannan ; Zhang, Yu ; Das, Shoubhik:
The efficient synthesis of three-membered rings via photo- and electrochemical strategies.
In: Chemical Science. Bd. 15 (2024) Heft 34 . - S. 13576-13604.
ISSN 2041-6539
DOI der Verlagsversion: https://doi.org/10.1039/D4SC02512A

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Abstract

Three-membered rings, such as epoxides, aziridines, oxaziridines, cyclopropenes, vinyloxaziridines, and azirines, are recognized as crucial pharmacophores and building blocks in organic chemistry and drug discovery. Despite the significant advances in the synthesis of these rings through photo/electrochemical methods over the past decade, there has currently been no focused discussion and updated overviews on this topic. Therefore, we presented this review article on the efficient synthesis of three-membered rings using photo- and electrochemical strategies, covering the literature since 2015. In this study, a conceptual overview and detailed discussions were provided to illustrate the advancement of this field. Moreover, a brief discussion outlines the current challenges and opportunities in synthesizing the three-membered rings using these strategies.