Designte Spinnenseidenmaterialien für zellspezifische Interaktionen

Titelangaben

Trossmann, Vanessa T. ; Scheibel, Thomas:
Designte Spinnenseidenmaterialien für zellspezifische Interaktionen.
In: BIOspektrum. Bd. 29 (2023) . - S. 689-691.
ISSN 1868-6249
DOI der Verlagsversion: https://doi.org/10.1007/s12268-023-2026-4

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Abstract

Spider silk films are promising for regenerative medicine and tissue engineering due to their biocompatibility. However, without modifications spider silk films often interact little with cells. Thus, we developed two modification strategies to enhance and guide specific cell interaction: 1) We introduced topographical surface patterns as cellular anchoring points. 2) We fused short cell adhesive peptide sequences to spider silk providing chemical interaction sites for cell receptors.