Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella mycetomatis

Titelangaben

Ma, Jingyi ; Todd, Matthew ; van de Sande, Wendy W. J. ; Biersack, Bernhard:
Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella mycetomatis.
In: Chemistry & Biodiversity. Bd. 20 (2023) Heft 5 . - e202300151.
ISSN 1612-1880
DOI der Verlagsversion: https://doi.org/10.1002/cbdv.202300151

Volltext

	Format: PDF Name: Chemistry Biodiversity - 2023 - Ma - Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella.pdf Version: Veröffentlichte Version Verfügbar mit der Lizenz Creative Commons BY-NC 4.0: Namensnennung, nicht kommerziell
	Download (613kB)

Abstract

Abstract Eumycetoma, the fungal form of the neglected tropical disease mycetoma, is a crippling infectious disease with low response rates to currently available antifungal drugs. In this study, a series of natural naphthoquinones and anthraquinones was evaluated for their activity against Madurella mycetomatis, which is the most common causative agent of eumycetoma. The metabolic activity of Madurella mycetomatis as well as the viability of Galleria mellonella larvae upon treatment with quinones was investigated. Several hydroxy-substituted naphthoquinones exhibited activity against Madurella mycetomatis. In particular, naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) was identified as a considerably active antifungal compound against Madurella mycetomatis (IC50=1.4 μM), while it showed reduced toxicity to Galleria mellonella larvae, which is a well-established in vivo invertebrate model for mycetoma drug studies.