Regiospecific Reduction of 4,6-Dinitrobenzimidazoles : Synthesis, Characterization, and Biological Evaluation

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00007233
URN to cite this document: urn:nbn:de:bvb:703-epub-7233-2

Title data

Abouelhaoul, El Alami ; El Kihel, Abdellatif ; Ahbala, Mustapha ; Sdassi, Hamid ; Köhler, Leonhard H. F. ; Bauchat, Patrick ; Roisnel, Thierry ; Khan, Tariq A. ; Al Nasr, Ibrahim S. ; Koko, Waleed S. ; Schobert, Rainer ; Biersack, Bernhard:
Regiospecific Reduction of 4,6-Dinitrobenzimidazoles : Synthesis, Characterization, and Biological Evaluation.
In: Chemistry & Biodiversity. Vol. 20 (2023) Issue 7 . - e202300191.
ISSN 1612-1880
DOI der Verlagsversion: https://doi.org/10.1002/cbdv.202300191

	Format: PDF Name: Chemistry Biodiversity - 2023 - Abouelhaoul - Regiospecific Reduction of 4 6‐Dinitrobenzimidazoles Synthesis .pdf Version: Published Version Available under License Creative Commons BY 4.0: Attribution
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Abstract

Abstract The regiospecific reduction of 4,6-dinitrobenzimidazole derivatives leading to the corresponding 4-amino-6-nitrobenzimidazoles was studied. The identification of the formed product structures was accomplished by spectroscopic and X-ray diffraction data. The anticancer and antiparasitic activities of the synthesized compounds were examined, and promising activities against Toxoplasma gondii and Leishmania major parasites were discovered for certain 4,6-dinitrobenzimidazoles in addition to moderate anticancer activities of the 4-amino-6-nitrobenzimidazole derivatives against T. gondii cells. However, the tumor cell experiments revealed a promising sensitivity of p53-negative colon cancer cells to these compounds.

Further data

Item Type:	Article in a journal
Keywords:	regiospecific reduction; 4,6-dinitrobenzimidazole; 4-amino-6-nitrobenzimidazoles; anticancer agents; antiparasitic agents
DDC Subjects:	500 Science > 540 Chemistry
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Organic Chemistry I - Univ.-Prof. Dr. Rainer Schobert Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Language:	English
Originates at UBT:	Yes
URN:	urn:nbn:de:bvb:703-epub-7233-2
Date Deposited:	16 Oct 2023 05:14
Last Modified:	16 Oct 2023 05:14
URI:	https://epub.uni-bayreuth.de/id/eprint/7233

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