Antiparasitic activities of bimetallic N-heterocyclic carbene gold(I) complexes with ferrocene ligands : Relevance of chlorido and phosphino ligands

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00007096
URN to cite this document: urn:nbn:de:bvb:703-epub-7096-5

Title data

Al Nasr, Ibrahim S. ; Weise, Markus ; Koko, Waleed S. ; Khan, Tariq A. ; Schobert, Rainer ; Biersack, Bernhard:
Antiparasitic activities of bimetallic N-heterocyclic carbene gold(I) complexes with ferrocene ligands : Relevance of chlorido and phosphino ligands.
In: Applied Organometallic Chemistry. Vol. 37 (2023) Issue 1 . - No. e6952.
ISSN 1099-0739
DOI der Verlagsversion: https://doi.org/10.1002/aoc.6952

	Format: PDF Name: Applied Organom Chemis - 2022 - Al Nasr - Antiparasitic activities of bimetallic N‐heterocyclic carbene gold I complexes.pdf Version: Published Version Available under License Creative Commons BY 4.0: Attribution
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Project information

Project financing:	Deutsche Forschungsgemeinschaft

Abstract

Gold(I) complexes carrying imidazole-2-ylidene ligands and ferrocene substituents were prepared. Their activities against protozoal Leishmania major and Toxoplasma gondii parasites were analyzed. Certain gold(I) complexes with chlorido and 1,1′-bis(triphenylphosphino)ferrocene ligands revealed promising antiparasitic effects. The new chlorido complexes 5b and 5c showed high activities against T. gondii tachyzoites and L. major promastigotes while the new ferrocene-bridged bis-gold(I) complexes 8a and 8b were particularly active against L. major amastigotes and considerably selective as to toxicity results from Vero cells and macrophages.

Further data

Item Type:	Article in a journal
Keywords:	antiparasitic drugs; ferrocene; gold; metal-based drugs; N-heterocyclic carbene
DDC Subjects:	500 Science > 540 Chemistry
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Organic Chemistry I - Univ.-Prof. Dr. Rainer Schobert Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Language:	English
Originates at UBT:	Yes
URN:	urn:nbn:de:bvb:703-epub-7096-5
Date Deposited:	14 Jul 2023 07:39
Last Modified:	14 Jul 2023 07:40
URI:	https://epub.uni-bayreuth.de/id/eprint/7096

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