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Interactions of cells with silk surfaces

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00004761
URN to cite this document: urn:nbn:de:bvb:703-epub-4761-8

Title data

Leal-Egaña, Aldo ; Scheibel, Thomas:
Interactions of cells with silk surfaces.
In: Journal of Materials Chemistry. Vol. 22 (2012) Issue 29 . - pp. 14330-14336.
ISSN 0959-9428
DOI der Verlagsversion: https://doi.org/10.1039/c2jm31174g

Format:	PDF
Name:	c2jm31174g.pdf
Version:	Published Version
Available under License	German copyright law. This contribution is freely accessible with the consent of the copyright holder on the basis of an (DFG-funded) alliance or national license. The document may be used free of charge for personal use. In addition, the reproduction, editing, distribution and any kind of exploitation require the written consent of the respective rights holder.

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Project information

Project financing:	U.S.Army Research Office (grant number W911NF-0810284).

Abstract

Polymers are often employed in tissue engineering to replace damaged extracellular matrix (ECM). During the last few decades silk proteins have been extensively investigated concerning their use as biopolymers for the generation of biocompatible, artificial scaffolds. Including the low or absence of immune-response and lack of cell toxicity, silk proteins present interesting properties useful for tissue engineering and organ repair. Since cell–matrix interactions define the behaviour of cells and posterior graft integration, this review is focused on the influence of surface properties of silk scaffolds (wettability, charge, elasticity and biodegradability) on the biological activity (adhesion, proliferation and/or migration) of cells cultured thereon. Further, it is highlighted how the origin of silk proteins (natural source, regenerated or recombinantly produced), as well as the scaffold morphology and its treatment/post-treatment influence the scaffold surface properties in the context of biomedical applications.

Further data

Item Type:	Article in a journal
Additional notes (visible to public):	ISI:000305966200002
DDC Subjects:	600 Technology, medicine, applied sciences > 620 Engineering
Institutions of the University:	Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel Faculties Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Biomaterials
Language:	English
Originates at UBT:	Yes
URN:	urn:nbn:de:bvb:703-epub-4761-8
Date Deposited:	04 Sep 2020 05:02
Last Modified:	04 Sep 2020 05:03
URI:	https://epub.uni-bayreuth.de/id/eprint/4761

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