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Recombinant Spider Silk–Silica Hybrid Scaffolds with Drug-Releasing Properties for Tissue Engineering Applications

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00004955
URN to cite this document: urn:nbn:de:bvb:703-epub-4955-1

Title data

Kumari, Sushma ; Bargel, Hendrik ; Scheibel, Thomas:
Recombinant Spider Silk–Silica Hybrid Scaffolds with Drug-Releasing Properties for Tissue Engineering Applications.
In: Macromolecular Rapid Communications. Vol. 41 (January 2020) Issue 1 . - p. 1900426. - 6 S..
ISSN 1521-3927
DOI der Verlagsversion: https://doi.org/10.1002/marc.201900426

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Name: marc.201900426.pdf
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Abstract

Fabricating biomaterials with antimicrobial activity to prevent the growth of detrimental microorganisms is of great scientific and practical interest. Here, composite materials comprising recombinant spider silk proteins and mesoporous silica nanoparticles (MSN) loaded with selected antibiotics and antimycotics are fabricated into films and hydrogels. The derived composite materials exhibit excellent antimicrobial properties with sustained release of antibiotics over the course of 15 days. Furthermore, antibiotics/antimycotics inclusion does not impair the cytocompatibility of the composite materials, all of which promote fibroblast cell adhesion and proliferation. Finally, processing of spider silk–MSN composite hydrogels using 3D printing is shown to enable the fabrication of patient‐specific antimicrobial implants to prevent infection in the near future.

Further data

Item Type: Article in a journal
Additional notes (visible to public): Special Issue: 100 Years of Macromolecular Chemistry.
This article also appears in:
Hot Topic: Mesoporous Materials
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Language: English
Originates at UBT: Yes
URN: urn:nbn:de:bvb:703-epub-4955-1
Date Deposited: 23 Jul 2020 05:51
Last Modified: 23 Jul 2020 05:51
URI: https://epub.uni-bayreuth.de/id/eprint/4955

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