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URN to cite this document: urn:nbn:de:bvb:703-epub-9127-0
Title data
Herz, Julian ; Weigel, Carina ; Scheder, Leonie ; Zarivach, Raz ; Algov, Itay ; Chemla, Yonatan ; Popp, Felix ; Riese, Cornelius N. ; Charsooghi, Mohammad A. ; Alfonta, Lital ; Meijler, Michael M. ; Schüler, Dirk ; Faivre, Damien ; Pfeiffer, Daniel:
A Two-Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto-Aerotaxis.
In: Advanced Science.
Vol. 12
(2025)
Issue 34
.
- e17315.
ISSN 2198-3844
DOI der Verlagsversion: https://doi.org/10.1002/advs.202417315
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Project information
| Project title: |
Project's official title Project's id Molecular mechanism of magneto-aerotaxis in bacteria 228478880 Mikroevolutionäre Anpassungen magnetotaktischer Bakterien an Polaritätsänderungen des Erdmagnetfelds 521548282 Molekulare Mechanismen der bakteriellen Magneto-Aerotaxis 525457187 Open Access Publizieren No information |
|---|---|
| Project financing: |
Deutsche Forschungsgemeinschaft |
Abstract
Bacteria in changing environments rely on motility and sensory mechanisms to locate optimal conditions. This process depends on specialized chemoreceptors to sense environmental stimuli. Exceptionally high numbers of chemoreceptor genes are present in magnetotactic bacteria (MTB), which combine magnetic alignment via intracellular magnetic nanoparticles (magnetosomes) and oxygen sensing for a unique navigation strategy toward low-oxygen zones, called magneto-aerotaxis. However, chemoreceptors for aerotaxis in MTB have not been experimentally identified. This study examines chemoreceptors in the model MTB Magnetospirillum gryphiswaldense. Gene deletion analysis shows that M. gryphiswaldense relies on a complex and partly redundant set of chemoreceptors to sense oxygen. Within this diverse repertoire of chemoreceptors, a receptor formed by two interacting proteins is identified that plays a key role in aerotaxis. Interaction assays and microscopy confirm that both proteins interact within polar-lateral regions in the cell. Moreover, genetic, biochemical, and motility experiments demonstrate that the chemoreceptor complex promotes a cellular response away from oxygen via the redox cofactor flavin adenine dinucleotide (FAD), independent of magnetic fields. These findings provide first insights into how MTB control oxygen sensing at the molecular level, shedding light on the mechanisms underlying bacterial navigation and highly complex chemosensory systems.
Further data
| Item Type: | Article in a journal |
|---|---|
| Keywords: | aerotaxis; chemoreceptor; magnetosome; magnetospirillum; magnetotaxis |
| DDC Subjects: | 500 Science > 570 Life sciences, biology |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Microbiology > Chair Microbiology - Univ.-Prof. Dr. Dirk Schüler Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Microbiology |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-9127-0 |
| Date Deposited: | 16 Apr 2026 11:12 |
| Last Modified: | 16 Apr 2026 11:13 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/9127 |
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