An Atomically Dispersed Photocatalyst for Undirected para‐Selective C–H bond Functionalizations

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00009027
URN to cite this document: urn:nbn:de:bvb:703-epub-9027-5

Title data

Pradhan, Suman ; Hu, Jun ; Ren, Peng ; Qin, Yuman ; Jain, Noopur ; Monti, Susanna ; Barcaro, Giovanni ; Jaworski, Aleksander ; Dai, Xingchao ; Rabeah, Jabor ; Silvestre-Albero, Joaquin ; Celorrio, Veronica ; Rokicińska, Anna ; Kuśtrowski, Piotr ; Van Aert, Sandra ; Bals, Sara ; Das, Shoubhik:
An Atomically Dispersed Photocatalyst for Undirected para‐Selective C–H bond Functionalizations.
In: Angewandte Chemie International Edition. Vol. 64 (2025) Issue 33 . - e202508512.
ISSN 1521-3773
DOI der Verlagsversion: https://doi.org/10.1002/anie.202508512

	Format: PDF Name: Angew Chem Int Ed - 2025 - Pradhan - An Atomically Dispersed Photocatalyst for Undirected para‐Selective C H Bond.pdf Version: Published Version Available under License Creative Commons BY 4.0: Attribution
	Download (4MB)

Project information

Project title:	Project's official title Project's id Open Access Publizieren No information

Abstract

Regioselective C–H bond functionalization is pivotal in modern scientific exploration, offering solutions for achieving novel synthetic methodologies and pharmaceutical development. In this aspect, achieving exceptional regioselective functionalization, like para-selective products in electron-poor aromatics, diverges from traditional methods. Leveraging the advantages of atomically dispersed photocatalysts, we designed a robust photocatalyst for an unconventional regioselective aromatic C–H bond functionalization. This innovation enabled para-selective trifluoromethylations of electron-deficient meta-directing aromatics (-NO2, -CF3, -CN, etc.), which is entirely orthogonal to the traditional approaches. Mechanistic experiments and DFT analysis confirmed the interaction between Cu-atom and the aromatic substrate, alongside the photocatalyst's molecular arrangement, driving selective exposure of the para-selective functionalization. This strategic approach elucidated pathways for precise molecular transformations, advancing the frontier of regioselective C–H bond functionalization by using atomically dispersed photocatalysts in organic synthesis.

Further data

Item Type:	Article in a journal
DDC Subjects:	500 Science > 540 Chemistry
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry I - Photo- und Elektrokatalyse für Nachhaltigkeit > Chair Organic Chemistry I - Photo- und Elektrokatalyse für Nachhaltigkeit - Univ.-Prof. Dr. Shoubhik Das Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry I - Photo- und Elektrokatalyse für Nachhaltigkeit
Language:	English
Originates at UBT:	Yes
URN:	urn:nbn:de:bvb:703-epub-9027-5
Date Deposited:	26 Mar 2026 13:42
Last Modified:	26 Mar 2026 13:43
URI:	https://epub.uni-bayreuth.de/id/eprint/9027

Download Statistics

Download Statistics

Download Statistics

Downloads

Downloads per month over past year