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URN to cite this document: urn:nbn:de:bvb:703-epub-9019-4
Title data
Höppener, Christiane ; Sobotta, Fabian H. ; Hoeppener, Stephanie ; Deckert, Volker ; Brendel, Johannes C.:
Unraveling the Hierarchical Self-Assembly of Amphiphilic Block Copolymer-Peptide Conjugates by Tip-Enhanced Raman Spectroscopy.
In: Small.
Vol. 21
(2025)
Issue 32
.
- 2502157.
ISSN 1613-6829
DOI der Verlagsversion: https://doi.org/10.1002/smll.202502157
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Project information
| Project title: |
Project's official title Project's id SFB 1278: Polymerbasierte Nanopartikel-Bibliotheken für die Entwicklung zielgerichteter anti-inflammatorischer Strategien 316213987 Supramolekulare Polymerbürsten als Wirkstoffträgersysteme – Aufbau definierter und reaktiver Systeme 358263073 Nanostrukturierung reaktiver Polymere – Von funktionellen Wirkstoffträgern zu hierarchisch strukturierten, lebensähnlichen Systemen 517761335 Vom Monomer zur Nanostruktur in einem Schritt: Schaltbare polymerisationsinduzierte Selbstassemblierung (PIESA) als künstliches Reaktions-Assemblierungsnetzwerk 525180722 Open Access Publizieren No information |
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| Project financing: |
Deutsche Forschungsgemeinschaft |
Abstract
Self-assembly of block copolymers in solution provides access to different nanostructures depending on block composition and processing conditions. However, more complex hierarchical nanostructures as found in nature remain challenging to achieve. In this study, the influence of a ?-sheet forming tetrapeptide sequence (GFFG) is investigated at the interface of an amphiphilic block copolymer based on poly(butyl acrylate) (PBA) and poly(ethylene oxide) (PEO). Using atomic force microscopy (AFM) and tip-enhanced Raman spectroscopy (TERS), nanoscale insights are provided into the structural organisation and mechanical properties of these hybrid materials. Both the tetrapeptide-containing block copolymer and a control block copolymer without the peptide linker form wormlike micelles in water. However, the incorporation of the peptide linker alters the micelle morphology by increasing the contour length sixfold compared to the control polymer and by altering the mechanical properties of the wormlike micelles. TERS analysis confirms the presence of ordered ?-sheet structures at the hydrophilic/hydrophobic interface, which increase the bending stiffness of the micelles. The introduction of additional secondary interactions, such as those induced by the peptide linker, therefore appears as an interesting lever to manipulate the structure formation and mechanical properties block copolymer micelles, opening up interesting design strategies for tailor-made hierarchically structured nanomaterials.
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