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Biofabrication of Composite Bioink-Nanofiber Constructs : Effect of Rheological Properties of Bioinks on 3D (Bio)Printing and Cells Interaction with Aligned Touch Spun Nanofibers

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00007525
URN zum Zitieren der Version auf EPub Bayreuth: urn:nbn:de:bvb:703-epub-7525-3

Titelangaben

Kitana, Waseem ; Levario Diaz, Victoria ; Cavalcanti-Adam, Elisabetta Ada ; Ionov, Leonid:
Biofabrication of Composite Bioink-Nanofiber Constructs : Effect of Rheological Properties of Bioinks on 3D (Bio)Printing and Cells Interaction with Aligned Touch Spun Nanofibers.
In: Advanced Healthcare Materials. Bd. 13 (2024) Heft 6 . - 2303343.
ISSN 2192-2659
DOI der Verlagsversion: https://doi.org/10.1002/adhm.202303343

Volltext

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Angaben zu Projekten

Projektfinanzierung: Deutsche Forschungsgemeinschaft
IO 68/14-1 326998133 - TRR 225 subproject A08

Abstract

This paper reports on a novel approach for the fabrication of composite multilayered bioink-nanofibers construct. This work achieves this by using a hands-free 3D (bio)printing integrated touch-spinning approach. Additionally, this work investigates the interaction of fibroblasts in different bioinks with the highly aligned touch-spun nanofibers. This work conducts a comprehensive characterization of the rheological properties of the inks, starting with low-strain oscillatory rheology to analyze the viscoelastic behavior, when the material structure remains intact. Moreover, this work performs amplitude sweeps to investigate the stability of the inks under large deformations, rotational rheology to examine the shear thinning profile, and a three-step creep experiment to study time-dependent rheological behavior. The obtained rheological results are correlated to visual observation of the flow behavior of inks. These behaviors span from an ink with zero-shear viscosity, very weak shear thinning, and no thixotropic behavior to inks exhibiting flow stress, pronounced shear thinning, and thixotropy. It is demonstrated that inks have an essential effect on cell behavior. While all bioinks allow a preferred directionality of the fibroblasts along the fiber direction, cells tend to form aggregates in bioinks with higher viscosity, and a considerable number of agglomerates are observed in the presence of laponite-RD.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Keywords: 3D biofabrication; bioink; cell motility; cell orientation; extrusion 3D
(bio)printing; rheology; touch-spinning
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
600 Technik, Medizin, angewandte Wissenschaften > 600 Technik
Institutionen der Universität: Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Zelluläre Biomechanik > Lehrstuhl Zelluläre Biomechanik - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation > Professur Biofabrikation - Univ.-Prof. Dr. Leonid Ionov
Fakultäten
Fakultäten > Fakultät für Ingenieurwissenschaften
Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Zelluläre Biomechanik
Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation
Sprache: Englisch
Titel an der UBT entstanden: Ja
URN: urn:nbn:de:bvb:703-epub-7525-3
Eingestellt am: 11 Mrz 2024 08:51
Letzte Änderung: 11 Mrz 2024 08:52
URI: https://epub.uni-bayreuth.de/id/eprint/7525

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