Rational design of N-heterocyclic compound classes via regenerative cyclization of diamines

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00007477
URN to cite this document: urn:nbn:de:bvb:703-epub-7477-5

Title data

Fertig, Robin ; Leowsky-Künstler, Felix ; Irrgang, Torsten ; Kempe, Rhett:
Rational design of N-heterocyclic compound classes via regenerative cyclization of diamines.
In: Nature Communications. Vol. 14 (2023) . - 595.
ISSN 2041-1723
DOI der Verlagsversion: https://doi.org/10.1038/s41467-023-36220-w

	Format: PDF Name: s41467-023-36220-w.pdf Version: Published Version Available under License Creative Commons BY 4.0: Attribution
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Abstract

The discovery of reactions is a central topic in chemistry and especially interesting if access to compound classes, which have not yet been synthesized, is permitted. N-Heterocyclic compounds are very important due to their numerous applications in life and material science. We introduce here a consecutive three-component reaction, classes of N-heterocyclic compounds, and the associated synthesis concept (regenerative cyclisation). Our reaction starts with a diamine, which reacts with an amino alcohol via dehydrogenation, condensation, and cyclisation to form a new pair of amines that undergoes ring closure with an aldehyde, carbonyldiimidazole, or a dehydrogenated amino alcohol. Hydrogen is liberated in the first reaction step and the dehydrogenation catalyst used is based on manganese.

Further data

Item Type:	Article in a journal
DDC Subjects:	500 Science 500 Science > 540 Chemistry
Institutions of the University:	Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II > Chair Inorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe
Language:	English
Originates at UBT:	Yes
URN:	urn:nbn:de:bvb:703-epub-7477-5
Date Deposited:	20 Feb 2024 07:40
Last Modified:	20 Feb 2024 07:42
URI:	https://epub.uni-bayreuth.de/id/eprint/7477

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