Manganese-catalyzed Dehydrogenation of Amido Alcohols with Liberation of Hydrogen for the Synthesis of Oxazoles

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00007354
URN to cite this document: urn:nbn:de:bvb:703-epub-7354-3

Title data

Leinert, Max ; Irrgang, Torsten ; Kempe, Rhett:
Manganese-catalyzed Dehydrogenation of Amido Alcohols with Liberation of Hydrogen for the Synthesis of Oxazoles.
In: ChemCatChem. Vol. 15 (2023) Issue 22 . - e202301042.
ISSN 1867-3899
DOI der Verlagsversion: https://doi.org/10.1002/cctc.202301042

	Format: PDF Name: ChemCatChem - 2023 - Leinert - Manganese‐catalyzed Dehydrogenation of Amido Alcohols with Liberation of Hydrogen for the.pdf Version: Published Version Available under License Creative Commons BY 4.0: Attribution
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Project information

Project financing:	Deutsche Forschungsgemeinschaft

Abstract

Abstract Syntheses of important classes of (heterocyclic) compounds, the sustainable generation of hydrogen, and the use of abundantly available metals are highly desirable. We introduce here a catalytic oxazole synthesis. Our reaction is a regio selective, one-pot reaction and starts from esters and amino alcohols. Both are abundantly and diversely available and inexpensive starting materials. Hydrogen is liberated during the reaction and a molecular earth-abundant metal catalyst, a Mn(I) compound, mediates the reaction most effectively - and more efficiently than Ir and Ru catalysts. None of the oxazole derivatives synthesized, except the screening substrate and an active ingredient of a drug (an application), have been reported in literature yet.

Further data

Item Type:	Article in a journal
Keywords:	amino alcohols; dehydrogenation; esters; manganese; oxazoles
DDC Subjects:	500 Science > 540 Chemistry
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II > Chair Inorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II
Language:	English
Originates at UBT:	Yes
URN:	urn:nbn:de:bvb:703-epub-7354-3
Date Deposited:	13 Dec 2023 07:57
Last Modified:	21 Dec 2023 05:49
URI:	https://epub.uni-bayreuth.de/id/eprint/7354

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