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URN to cite this document: urn:nbn:de:bvb:703-epub-7298-7
Title data
Machnik, Peter ; Biazar, Nastaran ; Schuster, Stefan:
Recordings in an integrating central neuron reveal the mode of action of isoeugenol.
In: Communications Biology.
Vol. 6
(2023)
Issue 1
.
- 309.
ISSN 2399-3642
DOI der Verlagsversion: https://doi.org/10.1038/s42003-023-04695-4
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Project's official title Project's id Open Access Publizieren No information |
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| Project financing: |
Deutsche Forschungsgemeinschaft |
Abstract
Although isoeugenol is one of the most widely used anesthetics in fish, its actual mode of action and thus its applicability for particular interventions is poorly understood. Here we determined effects of isoeugenol on various aspects of sensory and neural function, taking advantage of intracellular in vivo recordings in a uniquely suited identified neuron, the Mauthner neuron in the brain of goldfish. We show that isoeugenol strongly affects hearing and vision, but sensitivity and time course of action differed largely in these two senses. The action potential, chemical and electric synaptic transmission at the central neuron were not affected at low but efficient anesthesia. Effects seen at high concentration thereby do not support current views of how isoeugenol might act on central neurons. We show that isoeugenol is highly useful to anesthetize fish for handling, but that in more severe treatment its application needs to be carefully adapted to task.
Further data
| Item Type: | Article in a journal |
|---|---|
| DDC Subjects: | 500 Science > 570 Life sciences, biology |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-7298-7 |
| Date Deposited: | 09 Nov 2023 07:21 |
| Last Modified: | 09 Nov 2023 07:22 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/7298 |
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