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Thoroughly Hydrophilized Electrospun Poly(L-Lactide)/ Poly(ε-Caprolactone) Sponges for Tissue Engineering Application

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00007292
URN to cite this document: urn:nbn:de:bvb:703-epub-7292-3

Title data

Xu, Chengzhang ; Cheong, Jun Young ; Mo, Xiumei ; Jérôme, Valérie ; Freitag, Ruth ; Agarwal, Seema ; Gharibi, Reza ; Greiner, Andreas:
Thoroughly Hydrophilized Electrospun Poly(L-Lactide)/ Poly(ε-Caprolactone) Sponges for Tissue Engineering Application.
In: Macromolecular Bioscience. Vol. 23 (2023) Issue 11 . - 2300143.
ISSN 1616-5195
DOI der Verlagsversion: https://doi.org/10.1002/mabi.202300143

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Abstract

Biodegradable electrospun sponges are of interest for various applications including tissue engineering, drug release, dental therapy, plant protection, and plant fertilization. Biodegradable electrospun poly (L-lactide)/poly(ε-caprolactone) (PLLA/PCL) blend fiber-based sponge with hierarchical pore structure is inherently hydrophobic, which is disadvantageous for application in tissue engineering, fertilization, and drug delivery. We report contact angles and model studies for staining with a hydrophilic dye for untreated, plasma-treated, and surfactant treated PLLA/PCL sponges. Thorough hydrophilization of PLLA/PCL sponges was found only with the surfactant treated sponges. The MTT assay on the leachates from the sponges did not indicate any cell incompatibility. Furthermore, the cell proliferation and penetration of the hydrophilized sponges were verified by in vitro cell culture studies using MG63 and human fibroblast cells.

Further data

Item Type: Article in a journal
Keywords: polylactide; electrospun sponges; hydrophilization; human cell tests
DDC Subjects: 500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 600 Technology
600 Technology, medicine, applied sciences > 610 Medicine and health
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Language: English
Originates at UBT: Yes
URN: urn:nbn:de:bvb:703-epub-7292-3
Date Deposited: 09 Nov 2023 05:53
Last Modified: 09 Nov 2023 05:54
URI: https://epub.uni-bayreuth.de/id/eprint/7292

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