High Strength and High Toughness Electrospun Multifibrillar Yarns with Highly Aligned Hierarchy Intended as Anisotropic Extracellular Matrix

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00007110
URN to cite this document: urn:nbn:de:bvb:703-epub-7110-9

Title data

Liao, Xiaojian ; Jérôme, Valérie ; Agarwal, Seema ; Freitag, Ruth ; Greiner, Andreas:
High Strength and High Toughness Electrospun Multifibrillar Yarns with Highly Aligned Hierarchy Intended as Anisotropic Extracellular Matrix.
In: Macromolecular Bioscience. Vol. 22 (2022) Issue 12 . - 2200291.
ISSN 1616-5195
DOI der Verlagsversion: https://doi.org/10.1002/mabi.202200291

	Format: PDF Name: Macromolecular Bioscience - 2022 - Liao - High Strength and High Toughness Electrospun Multifibrillar Yarns with Highly.pdf Version: Published Version Available under License Creative Commons BY 4.0: Attribution
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Abstract

Abstract Electrospun nanofibers can be effectively used as a surrogate for extracellular matrices (ECMs). However, in the context of cellular mechanobiology, their mechanical performances could be enhanced by using nanofibrous materials with a high level of structural organization. Herein, we developed multifibrillar yarns with superior mechanical performance based on biocompatible polyacrylonitrile as surrogate ECM. Nearly-perfect aligned nanofibers along with the axis of the multifibrillar yarn were prepared. These highly aligned yarns exhibit high strength, high toughness, good stress relaxation behavior, and are robust enough for technical or medical applications. Further, we analyzed the influence of the highly aligned-hierarchical topological structure of the material on cell proliferation and cell orientation using cells derived from epithelial and connective tissues. Compared to non-oriented electrospun multifibrillar yarns and flat films, the well-ordered topology in the electrospun polyacrylonitrile multifibrillar yarns triggers an improved proliferation of fibroblasts and epithelial cells. The fibroblast acquired an elongated morphology analogous to their behavior in the natural ECM. Hence, this heterogeneous multifibrillar material could be used to restore or reproduce the ECM for tissue engineering applications, notably in the skeletal muscle and tendon. This article is protected by copyright. All rights reserved

Further data

Item Type:	Article in a journal
Keywords:	anisotropic; electrospinning; extracellular matrix; high strength; high toughness
DDC Subjects:	500 Science > 570 Life sciences, biology 600 Technology, medicine, applied sciences 600 Technology, medicine, applied sciences > 600 Technology 600 Technology, medicine, applied sciences > 610 Medicine and health
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Language:	English
Originates at UBT:	Yes
URN:	urn:nbn:de:bvb:703-epub-7110-9
Date Deposited:	17 Jul 2023 08:36
Last Modified:	17 Jul 2023 08:37
URI:	https://epub.uni-bayreuth.de/id/eprint/7110

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