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URN to cite this document: urn:nbn:de:bvb:703-epub-6882-9
Title data
Welzel, Georg ; Schuster, Stefan:
Connexins evolved after early chordates lost innexin diversity.
In: eLife.
Vol. 11
(January 2022)
.
- No. e74422.
ISSN 2050-084X
DOI der Verlagsversion: https://doi.org/10.7554/eLife.74422
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Project information
| Project title: |
Project's official title Project's id Open Access Publizieren No information |
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| Project financing: |
Deutsche Forschungsgemeinschaft |
Abstract
Gap junction channels are formed by two unrelated protein families. Non-chordates use the primordial innexins, while chordates use connexins that superseded the gap junction function of innexins. Chordates retained innexin-homologs, but N-glycosylation prevents them from forming gap junctions. It is puzzling why chordates seem to exclusively use the new gap junction protein and why no chordates should exist that use non-glycosylated innexins to form gap junctions. Here, we identified glycosylation sites of 2388 innexins from 174 non-chordate and 276 chordate species. Among all chordates, we found not a single innexin without glycosylation sites. Surprisingly, the glycosylation motif is also widespread among non-chordate innexins indicating that glycosylated innexins are not a novelty of chordates. In addition, we discovered a loss of innexin diversity during early chordate evolution. Most importantly, lancelets, which lack connexins, exclusively possess only one highly conserved innexin with one glycosylation site. A bottleneck effect might thus explain why connexins have become the only protein used to form chordate gap junctions.
Further data
| Item Type: | Article in a journal |
|---|---|
| Keywords: | gap junction evolution; innexin; pannexin; connexin; N-glycosylation |
| DDC Subjects: | 500 Science > 570 Life sciences, biology |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-6882-9 |
| Date Deposited: | 13 Mar 2023 08:12 |
| Last Modified: | 13 Mar 2023 08:14 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/6882 |
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