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URN to cite this document: urn:nbn:de:bvb:703-epub-6524-2
Title data
Speckner, Konstantin ; Weiss, Matthias:
Single-Particle Tracking Reveals Anti-Persistent Subdiffusion in Cell Extracts.
In: Entropy.
Vol. 23
(13 July 2021)
Issue 7
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- No. 892.
ISSN 1099-4300
DOI der Verlagsversion: https://doi.org/10.3390/e23070892
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Abstract
Single-particle tracking (SPT) has become a powerful tool to quantify transport phenomena in complex media with unprecedented detail. Based on the reconstruction of individual trajectories, a wealth of informative measures become available for each particle, allowing for a detailed comparison with theoretical predictions. While SPT has been used frequently to explore diffusive transport in artificial fluids and inside living cells, intermediate systems, i.e., biochemically active cell extracts, have been studied only sparsely. Extracts derived from the eggs of the clawfrog Xenopus laevis, for example, are known for their ability to support and mimic vital processes of cells, emphasizing the need to explore also the transport phenomena of nano-sized particles in such extracts. Here, we have performed extensive SPT on beads with 20 nm radius in native and chemically treated Xenopus extracts. By analyzing a variety of distinct measures, we show that these beads feature an anti-persistent subdiffusion that is consistent with fractional Brownian motion. Chemical treatments did not grossly alter this finding, suggesting that the high degree of macromolecular crowding in Xenopus extracts equips the fluid with a viscoelastic modulus, hence enforcing particles to perform random walks with a significant anti-persistent memory kernel.
Further data
| Item Type: | Article in a journal |
|---|---|
| Keywords: | anomalous diffusion; random walk; single-particle tracking |
| DDC Subjects: | 500 Science > 530 Physics 500 Science > 570 Life sciences, biology |
| Institutions of the University: | Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Chair Experimental Physics I - Physics of Living Matter > Chair Experimental Physics I - Physics of Living Matter - Univ.-Prof. Dr. Matthias Weiss Faculties Faculties > Faculty of Mathematics, Physics und Computer Science Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Chair Experimental Physics I - Physics of Living Matter |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-6524-2 |
| Date Deposited: | 21 Jul 2022 04:57 |
| Last Modified: | 21 Jul 2022 04:57 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/6524 |
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