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URN to cite this document: urn:nbn:de:bvb:703-epub-5879-1
Title data
Schirmer, Elisabeth ; Schuster, Stefan ; Machnik, Peter:
Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains.
In: Communications Biology.
Vol. 4
(2021)
Issue 1
.
- No. 465.
ISSN 2399-3642
DOI der Verlagsversion: https://doi.org/10.1038/s42003-021-01966-w
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Project information
| Project title: |
Project's official title Project's id Reinhart Koselleck-project Schu1470/8 Open Access Publizieren No information |
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| Project financing: |
Deutsche Forschungsgemeinschaft |
Abstract
Bisphenols are important plasticizers currently in use and are released at rates of hundreds of tons each year into the biosphere. However, for any bisphenol it is completely unknown if and how it affects the intact adult brain, whose powerful homeostatic mechanisms could potentially compensate any effects bisphenols might have on isolated neurons. Here we analyzed the effects of one month of exposition to BPA or BPS on an identified neuron in the vertebrate brain, using intracellular in vivo recordings in the uniquely suited Mauthner neuron in goldfish. Our findings demonstrate an alarming and uncompensated in vivo impact of both BPA and BPS—at environmentally relevant concentrations—on essential communication functions of neurons in mature vertebrate brains and call for the rapid development of alternative plasticizers. The speed and resolution of the assay we present here could thereby be instrumental to accelerate the early testing phase of next-generation plasticizers.
Further data
| Item Type: | Article in a journal |
|---|---|
| Keywords: | Neurophysiology; Risk factors; Toxicology |
| DDC Subjects: | 500 Science > 500 Natural sciences |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-5879-1 |
| Date Deposited: | 29 Oct 2021 09:34 |
| Last Modified: | 06 Jul 2022 07:57 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/5879 |
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