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URN to cite this document: urn:nbn:de:bvb:703-epub-5754-4
Title data
Mafi, Mahsa ; Kushmaro, Ariel ; Greenblatt, Charles ; Agarwal, Seema ; Greiner, Andreas:
Poly(Vinyl Alcohol)-Hydrogel Microparticles with Soft Barrier Shell for the Encapsulation of Micrococcus luteus.
In: Macromolecular Bioscience.
Vol. 21
(2021)
Issue 5
.
- No. 2000419.
ISSN 1616-5187
DOI der Verlagsversion: https://doi.org/10.1002/mabi.202000419
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Project information
| Project financing: |
Deutsche Forschungsgemeinschaft |
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Abstract
The encapsulation of bacteria in polymers results in hybrid materials that are essential for the long-term biological activity of bacteria and formulations in practical applications. Here, the problem of bacterial escape and the exchange of metabolism products from hydrogel microparticles within an aqueous environment are addressed. Bacteria are encapsulated in chemically cross-linked poly(vinyl alcohol) (PVA) hydrogel-microparticles followed by their encapsulation in a pH-responsive and soft antibacterial shell of poly(N,N-diethylamino ethyl methacrylate) (PDEAEMA). This polymer shell acts selectively with regards to the mass transport in and out of the microparticle core and is affected by environmental parameters, such as pH and antibacterial effect. The pH-responsive PDEAEMA shell forms an open porous structure that accelerates nutrient transfer into the PVA core containing living Micrococcus luteus (M. luteus). Results show that the antibacterial effect of PDEAEMA retards the escape of bacteria up to 35 days when the shell is open. Additionally, the permeation of a small molecule into the gel, for example, methylene blue dye through the core/open-shell structure, certifies a flexible barrier for mass transport, which is required in the long term for the biological activity of encapsulated M. luteus.
Further data
| Item Type: | Article in a journal |
|---|---|
| Keywords: | antibacterial polymers; core/shell polymer microparticles; encapsulation;
Micrococcus luteus |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner Profile Fields > Advanced Fields > Polymer and Colloid Science Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Profile Fields Profile Fields > Advanced Fields |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-5754-4 |
| Date Deposited: | 02 Sep 2021 09:54 |
| Last Modified: | 02 Sep 2021 09:54 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/5754 |
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