URN to cite this document: urn:nbn:de:bvb:703-epub-5513-6
Title data
Hecker, Alexander ; Anger, Pamela ; Braaker, Philipp N. ; Schulze, Wolfram ; Schuster, Stefan:
High-resolution mapping of injury-site dependent functional recovery in a single axon in zebrafish.
In: Communications Biology.
Vol. 3
(2020)
Issue 1
.
- No. 307.
ISSN 2399-3642
DOI der Verlagsversion: https://doi.org/10.1038/s42003-020-1034-x
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Project information
Project title: |
Project's official title Project's id Open Access Publizieren No information |
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Project financing: |
Deutsche Forschungsgemeinschaft |
Abstract
In non-mammalian vertebrates, some neurons can regenerate after spinal cord injury. One of these, the giant Mauthner (M-) neuron shows a uniquely direct link to a robust survival-critical escape behavior but appears to regenerate poorly. Here we use two-photon microscopy in parallel with behavioral assays in zebrafish to show that the M-axon can regenerate very rapidly and that the recovery of functionality lags by just days. However, we also find that the site of the injury is critical: While regeneration is poor both close and far from the soma, rapid regeneration and recovery of function occurs for injuries between 10% and 50% of total axon length. Our findings show that rapid regeneration and the recovery of function can be studied at remarkable temporal resolution after targeted injury of one single M-axon and that the decision between poor and rapid regeneration can be studied in this one axon.
Further data
Item Type: | Article in a journal |
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Keywords: | Regeneration and repair in the nervous system; Spinal cord injury |
DDC Subjects: | 500 Science > 500 Natural sciences 500 Science > 590 Animals (Zoology) |
Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology |
Language: | English |
Originates at UBT: | Yes |
URN: | urn:nbn:de:bvb:703-epub-5513-6 |
Date Deposited: | 17 May 2021 09:23 |
Last Modified: | 17 May 2021 09:23 |
URI: | https://epub.uni-bayreuth.de/id/eprint/5513 |