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URN to cite this document: urn:nbn:de:bvb:703-epub-4945-6
Title data
Kempe, Rhett ; Schlagbauer, Martin ; Kallmeier, Fabian ; Irrgang, Torsten:
Manganese catalyzed ß‐methylation of alcohols by methanol.
In: Angewandte Chemie International Edition.
Vol. 59
(20 January 2020)
Issue 4
.
- pp. 1485-1490.
ISSN 1521-3773
DOI der Verlagsversion: https://doi.org/10.1002/anie.201912055
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Abstract
We report an earth‐abundant metal catalyzed double and single methylation of alcohols. A manganese catalyst, which operates at low catalyst loadings and short reaction times, mediates these reactions efficiently. A broad scope of primary and secondary alcohols including purely aliphatic examples and 1,2‐aminoalcohols can be methylated. In addition, alcohol methylation for the synthesis of pharmaceuticals has been demonstrated. The catalyst system tolerates many functional groups among them hydrogenation sensitive examples and upscaling is easily achieved. Mechanistic investigations are indicative of a borrowing hydrogen or hydrogen autotransfer mechanism involving a bimetallic K‐Mn catalyst. The catalyst accepts hydrogen as a proton and a hydride from alcohols efficiently and reacts with a chalcone via hydride transfer.
Further data
| Item Type: | Article in a journal |
|---|---|
| Additional notes (visible to public): | early view |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II > Chair Inorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-4945-6 |
| Date Deposited: | 21 Jul 2020 10:59 |
| Last Modified: | 21 Jul 2020 10:59 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/4945 |
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