in the repository
Title data
Welzel, Georg ; Schuster, Stefan:
Long-term potentiation in an innexin-based electrical synapse.
In: Scientific Reports.
Vol. 2018
(22 August 2018)
Issue 8
.
- No. 12579.
ISSN 2045-2322
DOI der Verlagsversion: https://doi.org/10.1038/s41598-018-30966-w
![[thumbnail of s41598-018-30966-w.pdf]](https://epub.uni-bayreuth.de/style/images/fileicons/application_pdf.png) |
|
||||||||
|
Download (3MB)
|
Project information
| Project title: |
Project's official title Project's id Open Access Publizieren No information |
|---|
Abstract
Electrical synapses are formed by two unrelated gap junction protein families, the primordial innexins (invertebrates) or the connexins (vertebrates). Although molecularly different, innexin- and connexin-based electrical synapses are strikingly similar in their membrane topology. However, it remains unclear if this similarity extends also to more sophisticated functions such as long-term potentiation which is only known in connexin-based synapses. Here we show that this capacity is not unique to connexin-based synapses. Using a method that allowed us to quantitatively measure gap-junction conductance we provide the first and unequivocal evidence of long-term potentiation in an innexin-based electrical synapse. Our findings suggest that long-term potentiation is a property that has likely existed already in ancestral gap junctions. They therefore could provide a highly potent system to dissect shared molecular mechanisms of electrical synapse plasticity.
Further data
| Item Type: | Article in a journal |
|---|---|
| Keywords: | Electrical synapses; long-term potentiation |
| DDC Subjects: | 500 Science |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-4242-6 |
| Date Deposited: | 27 Feb 2019 13:14 |
| Last Modified: | 07 Jul 2020 10:46 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/4242 |
Download Statistics