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Single-Particle Tracking Reveals Anti-Persistent Subdiffusion in Cell Extracts

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00006524
URN to cite this document: urn:nbn:de:bvb:703-epub-6524-2

Title data

Speckner, Konstantin ; Weiss, Matthias:
Single-Particle Tracking Reveals Anti-Persistent Subdiffusion in Cell Extracts.
In: Entropy. Vol. 23 (13 July 2021) Issue 7 . - No. 892.
ISSN 1099-4300
DOI der Verlagsversion: https://doi.org/10.3390/e23070892

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Abstract

Single-particle tracking (SPT) has become a powerful tool to quantify transport phenomena in complex media with unprecedented detail. Based on the reconstruction of individual trajectories, a wealth of informative measures become available for each particle, allowing for a detailed comparison with theoretical predictions. While SPT has been used frequently to explore diffusive transport in artificial fluids and inside living cells, intermediate systems, i.e., biochemically active cell extracts, have been studied only sparsely. Extracts derived from the eggs of the clawfrog Xenopus laevis, for example, are known for their ability to support and mimic vital processes of cells, emphasizing the need to explore also the transport phenomena of nano-sized particles in such extracts. Here, we have performed extensive SPT on beads with 20 nm radius in native and chemically treated Xenopus extracts. By analyzing a variety of distinct measures, we show that these beads feature an anti-persistent subdiffusion that is consistent with fractional Brownian motion. Chemical treatments did not grossly alter this finding, suggesting that the high degree of macromolecular crowding in Xenopus extracts equips the fluid with a viscoelastic modulus, hence enforcing particles to perform random walks with a significant anti-persistent memory kernel.

Further data

Item Type: Article in a journal
Keywords: anomalous diffusion; random walk; single-particle tracking
DDC Subjects: 500 Science > 530 Physics
500 Science > 570 Life sciences, biology
Institutions of the University: Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Chair Experimental Physics I - Physics of Living Matter > Chair Experimental Physics I - Physics of Living Matter - Univ.-Prof. Dr. Matthias Weiss
Faculties
Faculties > Faculty of Mathematics, Physics und Computer Science
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Chair Experimental Physics I - Physics of Living Matter
Language: English
Originates at UBT: Yes
URN: urn:nbn:de:bvb:703-epub-6524-2
Date Deposited: 21 Jul 2022 04:57
Last Modified: 21 Jul 2022 04:57
URI: https://epub.uni-bayreuth.de/id/eprint/6524

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