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Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00005879
URN to cite this document: urn:nbn:de:bvb:703-epub-5879-1

Title data

Schirmer, Elisabeth ; Schuster, Stefan ; Machnik, Peter:
Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains.
In: Communications Biology. Vol. 4 (2021) Issue 1 . - No. 465.
ISSN 2399-3642
DOI der Verlagsversion: https://doi.org/10.1038/s42003-021-01966-w

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Project information

Project title:
Project's official titleProject's id
Reinhart Koselleck-projectSchu1470/8

Project financing: Deutsche Forschungsgemeinschaft

Abstract

Bisphenols are important plasticizers currently in use and are released at rates of hundreds of tons each year into the biosphere. However, for any bisphenol it is completely unknown if and how it affects the intact adult brain, whose powerful homeostatic mechanisms could potentially compensate any effects bisphenols might have on isolated neurons. Here we analyzed the effects of one month of exposition to BPA or BPS on an identified neuron in the vertebrate brain, using intracellular in vivo recordings in the uniquely suited Mauthner neuron in goldfish. Our findings demonstrate an alarming and uncompensated in vivo impact of both BPA and BPS—at environmentally relevant concentrations—on essential communication functions of neurons in mature vertebrate brains and call for the rapid development of alternative plasticizers. The speed and resolution of the assay we present here could thereby be instrumental to accelerate the early testing phase of next-generation plasticizers.

Further data

Item Type: Article in a journal
Keywords: Neurophysiology; Risk factors; Toxicology
DDC Subjects: 500 Science > 500 Natural sciences
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology
Language: English
Originates at UBT: Yes
URN: urn:nbn:de:bvb:703-epub-5879-1
Date Deposited: 29 Oct 2021 09:34
Last Modified: 29 Oct 2021 09:35
URI: https://epub.uni-bayreuth.de/id/eprint/5879

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