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Recombinant Spider Silk Gels Derived from Aqueous–Organic Solvents as Depots for Drugs

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00005756
URN to cite this document: urn:nbn:de:bvb:703-epub-5756-5

Title data

Neubauer, Vanessa J. ; Trossmann, Vanessa T. ; Jacobi, Sofia ; Döbl, Annika ; Scheibel, Thomas:
Recombinant Spider Silk Gels Derived from Aqueous–Organic Solvents as Depots for Drugs.
In: Angewandte Chemie International Edition. Vol. 60 (2021) Issue 21 . - pp. 11847-11851.
ISSN 1521-3773
DOI der Verlagsversion: https://doi.org/10.1002/anie.202103147

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Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract

Hydrogels are widely used in various biomedical applications, as they cannot only serve as materials for biofabrication but also as depots for the administration of drugs. However, the possibilities of formulation of water-insoluble drugs in hydrogels are rather limited. Herein, we assembled recombinant spider silk gels using a new processing route with aqueous–organic co-solvents, and the properties of these gels could be controlled by the choice of the co-solvent. The presence of the organic co-solvent further enabled the incorporation of hydrophobic drugs as exemplarily shown for 6-mercaptopurine. The developed gels showed shear-thinning behaviour and could be easily injected to serve, for example, as drug depots, and they could even be 3D printed to serve as scaffolds for biofabrication. With this new processing route, the formulation of water-insoluble drugs in spider silk-based depots is possible, circumventing common pharmaceutical solubility issues.

Further data

Item Type: Article in a journal
Keywords: binary mixtures; co-solvent; hydrophobic effect; micro-heterogeneity; self-assembly
DDC Subjects: 600 Technology, medicine, applied sciences > 600 Technology
600 Technology, medicine, applied sciences > 620 Engineering
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Molecular Biosciences
Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Profile Fields
Language: English
Originates at UBT: Yes
URN: urn:nbn:de:bvb:703-epub-5756-5
Date Deposited: 02 Sep 2021 10:41
Last Modified: 02 Sep 2021 10:41
URI: https://epub.uni-bayreuth.de/id/eprint/5756

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