Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

Manganese catalyzed ß‐methylation of alcohols by methanol

DOI zum Zitieren der Version auf EPub Bayreuth: https://doi.org/10.15495/EPub_UBT_00004945
URN to cite this document: urn:nbn:de:bvb:703-epub-4945-6

Title data

Kempe, Rhett ; Schlagbauer, Martin ; Kallmeier, Fabian ; Irrgang, Torsten:
Manganese catalyzed ß‐methylation of alcohols by methanol.
In: Angewandte Chemie International Edition. Vol. 59 (20 January 2020) Issue 4 . - pp. 1485-1490.
ISSN 1521-3773
DOI der Verlagsversion: https://doi.org/10.1002/anie.201912055

[img]
Format: PDF
Name: anie.201912055.pdf
Version: Published Version
Available under License Creative Commons BY 4.0: Attribution
Download (1MB)

Abstract

We report an earth‐abundant metal catalyzed double and single methylation of alcohols. A manganese catalyst, which operates at low catalyst loadings and short reaction times, mediates these reactions efficiently. A broad scope of primary and secondary alcohols including purely aliphatic examples and 1,2‐aminoalcohols can be methylated. In addition, alcohol methylation for the synthesis of pharmaceuticals has been demonstrated. The catalyst system tolerates many functional groups among them hydrogenation sensitive examples and upscaling is easily achieved. Mechanistic investigations are indicative of a borrowing hydrogen or hydrogen autotransfer mechanism involving a bimetallic K‐Mn catalyst. The catalyst accepts hydrogen as a proton and a hydride from alcohols efficiently and reacts with a chalcone via hydride transfer.

Further data

Item Type: Article in a journal
Additional notes (visible to public): early view
DDC Subjects: 500 Science > 540 Chemistry
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Inorganic Chemistry II > Chair Inorganic Chemistry II - Univ.-Prof. Dr. Rhett Kempe
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Language: English
Originates at UBT: Yes
URN: urn:nbn:de:bvb:703-epub-4945-6
Date Deposited: 21 Jul 2020 10:59
Last Modified: 21 Jul 2020 10:59
URI: https://epub.uni-bayreuth.de/id/eprint/4945

Downloads

Downloads per month over past year