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Long-term potentiation in an innexin-based electrical synapse

DOI zum Zitieren dieses Dokuments: https://doi.org/10.1038/s41598-018-30966-w
URN to cite this document: urn:nbn:de:bvb:703-epub-4242-6

Title data

Welzel, Georg ; Schuster, Stefan:
Long-term potentiation in an innexin-based electrical synapse.
In: Scientific Reports. Vol. 2018 (22 August 2018) Issue 8 . - No. 12579.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-018-30966-w

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Abstract

Electrical synapses are formed by two unrelated gap junction protein families, the primordial innexins (invertebrates) or the connexins (vertebrates). Although molecularly different, innexin- and connexin-based electrical synapses are strikingly similar in their membrane topology. However, it remains unclear if this similarity extends also to more sophisticated functions such as long-term potentiation which is only known in connexin-based synapses. Here we show that this capacity is not unique to connexin-based synapses. Using a method that allowed us to quantitatively measure gap-junction conductance we provide the first and unequivocal evidence of long-term potentiation in an innexin-based electrical synapse. Our findings suggest that long-term potentiation is a property that has likely existed already in ancestral gap junctions. They therefore could provide a highly potent system to dissect shared molecular mechanisms of electrical synapse plasticity.

Further data

Item Type: Article in a journal
Keywords: Electrical synapses; long-term potentiation
DDC Subjects: 500 Science
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology
Language: English
Originates at UBT: Yes
URN: urn:nbn:de:bvb:703-epub-4242-6
Date Deposited: 27 Feb 2019 13:14
Last Modified: 27 Feb 2019 13:14
URI: https://epub.uni-bayreuth.de/id/eprint/4242

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