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URN to cite this document: urn:nbn:de:bvb:703-epub-9052-4
Title data
Voigt, Jonah L. ; Timmer, Jens ; Cavalcanti-Adam, Elisabetta Ada:
Substrate Stress Relaxation Regulates Cell-Mediated Assembly of Extracellular Matrix.
In: Advanced Functional Materials.
(2025)
.
- e09352.
ISSN 1616-3028
DOI der Verlagsversion: https://doi.org/10.1002/adfm.202509352
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Project information
| Project title: |
Project's official title Project's id SFB 1638: Umbau von zellulären Membranen – wie veränderte Form Funktion schafft 511488495 Function by Design: Cellular Hybrids No information Open Access Publizieren No information |
|---|---|
| Project financing: |
Deutsche Forschungsgemeinschaft High Tech Agenda Bayern |
Abstract
The viscoelasticity of the extracellular matrix (ECM) regulates diverse cellular functions, yet its influence in guiding ECM assembly and organization under physiologically relevant stiffness remains poorly defined. In this study, silicone-based substrates with comparable stiffness (≈80 kPa) but distinct stress relaxation profiles are used to investigate how matrix viscoelasticity affects cellular mechanosensing and cell-mediated ECM remodeling in the stiff regime. Increased substrate stress relaxation enhances fibronectin reorganization, focal adhesion maturation, and traction force generation for similar fibronectin surface density. Cells on viscoelastic substrates exhibit increased nuclear localization of YAP and form β1 integrin-enriched adhesions, correlating with localized ECM reorganization. These findings reveal that mechanical properties alone, decoupled from biochemical cues, are sufficient to direct ECM reorganization. This platform allows dissecting mechano-regulated tissue remodeling and designing mechanically tunable biomaterials for regenerative medicine.
Further data
| Item Type: | Article in a journal |
|---|---|
| Keywords: | cell adhesion; elastomer; extracellular matrix assembly; substrate stress relaxation; viscoelasticity |
| DDC Subjects: | 600 Technology, medicine, applied sciences |
| Institutions of the University: | Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam Faculties Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-9052-4 |
| Date Deposited: | 31 Mar 2026 07:51 |
| Last Modified: | 31 Mar 2026 07:52 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/9052 |
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