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URN to cite this document: urn:nbn:de:bvb:703-epub-8760-3
Title data
Maric, Benedikt ; Schuster, Stefan ; Machnik, Peter:
Exposure to phthalate plasticizer compromises normal brain function in an adult vertebrate.
In: Ecotoxicology and Environmental Safety.
Vol. 286
(2024)
.
- 117187.
ISSN 1090-2414
DOI der Verlagsversion: https://doi.org/10.1016/j.ecoenv.2024.117187
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Project information
| Project title: |
Project's official title Project's id Plastische und funktionell stabile Repräsentation von Gesetzmäßigkeiten der Umwelt in einem kleinen Entscheidungs-Netzwerk 101025387 Open Access Publizieren No information |
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| Project financing: |
Deutsche Forschungsgemeinschaft |
Abstract
Phthalates are key additives in many plastic products and among the most frequently used plasticizers. The release of some of them into the environment has been shown to have serious effects on development and reproduction. Based on such effects, diisononyl phthalate (DINP) has been advocated as a safer alternative to di-2-ethylhexyl phthalate (DEHP). Recently, it has been suggested that DEHP may affect the vertebrate blood-brain barrier. This could have serious consequences not only for the developing, but also for the adult brain. Here we tested for such impact on neuronal function and demonstrate acute exposure effects of both plasticizers on fundamental aspects of brain function in an adult vertebrate. We used the Mauthner neuron in the hindbrain of fish and its diverse inputs from various sensory systems as a model. After exposing intact goldfish to environmentally relevant plasticizer concentration (either 100 µg L–1, or 10 µg L–1), we show from in vivo intracellular recording that one month of environmental exposure to DEHP or DINP affected the sensory input to this central neuron, offset the balance between excitation and inhibition, and reduced its conduction speed by 20 . The effects of both plasticizers were strong even at the concentration of 10 µg L–1. In an adult vertebrate, our findings thus demonstrate a previously neglected high sensitivity of various crucial brain functions to the acute exposure to phthalates.
Further data
| Item Type: | Article in a journal |
|---|---|
| Keywords: | Plasticizer, Phthalate, Plastic compound, Neuronal function, Brain function |
| DDC Subjects: | 600 Technology, medicine, applied sciences > 610 Medicine and health |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology > Chair Animal Physiology - Univ.-Prof. Dr. Stefan Schuster Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Physiology |
| Language: | English |
| Originates at UBT: | Yes |
| URN: | urn:nbn:de:bvb:703-epub-8760-3 |
| Date Deposited: | 16 Dec 2025 14:46 |
| Last Modified: | 16 Dec 2025 14:47 |
| URI: | https://epub.uni-bayreuth.de/id/eprint/8760 |
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